Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC1
نویسندگان
چکیده
Zachary Gerhart-Hines, Joseph T Rodgers, Olivia Bare, Carles Lerin, Seung-Hee Kim, Raul Mostoslavsky, Frederick W Alt, Zhidan Wu and Pere Puigserver* Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA, USA, Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, USA, Novartis Institutes for Biomedical Research Inc., Cambridge, MA, USA and Howard Hughes Medical Institute, Department of Genetics, The Children’s Hospital, CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA, USA
منابع مشابه
Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha.
In mammals, maintenance of energy and nutrient homeostasis during food deprivation is accomplished through an increase in mitochondrial fatty acid oxidation in peripheral tissues. An important component that drives this cellular oxidative process is the transcriptional coactivator PGC-1alpha. Here, we show that fasting induced PGC-1alpha deacetylation in skeletal muscle and that SIRT1 deacetyla...
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